V-Score Search

V-Score-Search is a web-based platform designed for the public to explore V-scores and VL-scores across protein clusters from five major databases: PHROG, VOG, KEGG, Pfam, and eggNOG. These scores serve as quantitative "virus-like signatures" that differentiate viral from non-viral protein families and genomes. We demonstrate their utility through specific use cases, including virus identification, prophage discovery, and the annotation of host-derived or metabolic proteins within viral genomes. By defining the likelihood of a protein family’s viral origin, V-scores and VL-scores enable diverse applications in viral genomics, ecology, and evolution. For detailed methodology, please refer to our paper (bioRxiv preprint); to implement these metrics in your own viral identification, visit our GitHub pipeline.

Citing V-Score-Search

If you find V-Score-Search useful, please consider citing the reference that describes this work:
Zhou K, Kosmopoulos JC, Colón ED, Badciong PJ, Anantharaman K. V- and VL-Scores Unveil Viral Signatures and Origins of Protein Families. ( https://www.biorxiv.org/content/10.1101/2024.10.24.619987v1 ).

Enter any type of accession or ID to jump to the page for V-scores and VL-scores associated with every protein cluster or family. You can also search by protein name.